Is COMT a Susceptibility Gene for Schizophrenia?
نویسندگان
چکیده
منابع مشابه
Is COMT a susceptibility gene for schizophrenia?
Catechol-O-methyl transferase (COMT) is a catabolic enzyme involved in the degradation of a number of bioactive molecules; of principal interest to psychiatry, these include dopamine. The enzyme is encoded by the COMT gene. COMT is located (along with 47 other genes) in a fragment of chromosome 22q11 which when deleted results in a complex syndrome, the psychiatric manifestations of which inclu...
متن کاملA haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.
The gene encoding catechol-O-methyltransferase (COMT) is a strong candidate for schizophrenia susceptibility, owing to the role of COMT in dopamine metabolism, and the location of the gene within the deleted region in velocardiofacial syndrome, a disorder associated with high rates of schizophrenia. Recently, a highly significant association was reported between schizophrenia and a COMT haploty...
متن کاملNo association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population
BACKGROUND The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. AIMS The aim of the present study was to investigate possible association between schizophrenia and Val158Met in a novel Arab population from Syria. METHODS AND MATERIALS 71 unrelated schizophrenic ...
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Schizophrenia (SCZ) is a severe and debilitating mental disorder, and the specific genetic factors that underlie the risk for SCZ remain elusive. The autism susceptibility candidate 2 (AUTS2) gene has been reported to be associated with autism, suicide, alcohol consumption, and heroin dependence. We hypothesized that AUTS2 might be associated with SCZ. In the present study, three polymorphisms ...
متن کاملHypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.
The variability in phenotypic presentations and the lack of consistency of genetic associations in mental illnesses remain a major challenge in molecular psychiatry. Recently, it has become increasingly clear that altered promoter DNA methylation could play a critical role in mediating differential regulation of genes and in facilitating short-term adaptation in response to the environment. Her...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2007
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbm019